Madsen and Hauser look for a killer with a background in chemistry, who likes to poison his victims; more information about Madsen's grandfather comes to light.
The team uses methods of the past to track former inmate Paxton Petty, who has returned to plant bombs in populated areas of San Francisco.
The facility's most violent brothers, Herman and Pinky Ames, find something amiss when they return to present-day Alcatraz.
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