Denny gets a disturbing prognosis about the progression of his disease; Catherine Piper returns; Jerry and Katie take on the case of a student fighting to keep her acceptance to Harvard.
Shirley's intimate Thanksgiving dinner with Carl Sack turns into a dysfunctional family affair when she invites Alan, Denny, Jerry, Katie, Edwin, and his 6-year-old foster son to join them.
Crane, Poole & Schmidt is in dire financial straits; Alan goes to the Supreme Court to get Denny access to a drug to slow the progression of Alzheimer's; Shirley and Carl plan their wedding; Denny has an important question for Alan.
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