When a woman is swallowed whole by a giant snake, the CSI team suspects that Horatio's nemesis, Clavo Cruz, is behind an operation that uses snakes to smuggle drugs into the country.
The murder of a bellboy during tourist season leaves detectives with many suspects, but the luggage he had been loading helps them to uncover a complex counterfeiting operation.
Horatio and the team race against time to find a killer who escaped from prison while helping to fight a fire in the Everglades; a local college student is found shot, but the blaze has destroyed the crime scene and evidence.
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