Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.
Dr. Addison Forbes Montgomery's struggles at Seattle Grace and her search for happiness in Los Angeles; a music video set to Mat Kearney's ``Breathe In Breathe Out''; a preview of the season.
The residents and interns treat the victims of a massive explosion at an apartment building; Mama Burke returns to collect her son's things; Lexie tries to have a heart-to-heart with unwilling Meredith.
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