Izzie's mother (Sharon Lawrence) pays her a surprise visit; Thatcher tries to make amends with Meredith and Lexie; Meredith and the Chief argue over a controversial case.
While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.
Derek and Meredith get ready for their wedding; college students injured in a car accident are admitted to the ER; Izzie starts experiencing familiar symptoms.
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