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Through Lexie, Meredith tries to get Derek interested in a patient's rare brain tumor; Callie ends up being annoyed when Mark and Arizona finally form a friendship; Teddy and Alex look into alternative surgeries for a superficial patient.
The residents try to impress Jackson's mother, Catherine Avery, when she comes to Seattle Grace to perform a groundbreaking surgery; Alex and Arizona encounter a familiar face in the ER; Bailey makes a choice about her love life.
Owen organizes a baseball game against Seattle Presbyterian; Lexie is unable to control her emotions when she sees Mark with a new woman; Alex fights for Zola; Richard talks to Meredith and Bailey about their feud.
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