Meredith becomes disenchanted with her ignorance of parts of Derek's life; Alex treats a patient whose religious beliefs jeopardize her chances for recovery; a 40-year-old pregnant woman with cancer disagrees with Cristina's advice.
Derek and Meredith try to be discreet after spending the night together at her house; George is reluctant to voice his suspicions that an anesthesiologist is drinking on the job.
The outbreak of a sexually transmitted disease affects several members of the hospital staff; Izzie and Cristina worry about a patient whose wife and daughter are at odds over his care.
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