A stampede at a comic book convention leads to an influx of colorful characters in the ER; Mark continues to make life difficult for Jackson; Ben returns and realizes Bailey has moved on.
The chief makes a decision that shocks everyone at Seattle Grace; Owen and Cristina attempt to find normalcy; April struggles in her new role; the fifth-year residents receive their first solo surgery assignments.
The residents try to impress Jackson's mother, Catherine Avery, when she comes to Seattle Grace to perform a groundbreaking surgery; Alex and Arizona encounter a familiar face in the ER; Bailey makes a choice about her love life.
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