Six weeks after Derek and Meredith ended their relationship, Meredith, Alex, Izzie and Cristina compete in a surgical contest, with Bailey serving as judge; George and Lexie adjust to their new, squalid apartment; Callie finds a friend in Erica.
Bailey's family faces a medical trauma just as her marriage falls apart; George's mother makes a surprise visit; a faith healer challenges Erica and Alex's belief in traditional medicine; Derek must deal with the aftermath of his kiss with Rose.
Addison returns to Seattle Grace to perform an operation and is surprised by all the changes in the lives of her former co-workers; Derek and Meredith's clinical trial has its first patient; Rebecca returns with shocking news for Alex.
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