Callie and Arizona's wedding is not coming together as they hoped it would; Alex seems to be the first choice for chief resident; Meredith and Derek make a life-changing decision; Dr. Perkins tempts Teddy with a proposition.
Everyone tries to help Callie and her baby recover; the sudden death of a clinical trial patient impacts Derek and Meredith in different ways; Teddy is surprised by a familiar face.
Work and personal pressures leave Meredith on edge; formal interviews for the chief resident position begin; Lucy and Alex's relationship is tested.
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