The outbreak of a sexually transmitted disease affects several members of the hospital staff; Izzie and Cristina worry about a patient whose wife and daughter are at odds over his care.
Meredith becomes disenchanted with her ignorance of parts of Derek's life; Alex treats a patient whose religious beliefs jeopardize her chances for recovery; a 40-year-old pregnant woman with cancer disagrees with Cristina's advice.
As Meredith and Cristina discuss their relationship woes at the Emerald City Bar, the bartender collapses.
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