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When a 200-year-old medicine jar shatters in a teenager's palm, she is admitted to the hospital with symptoms closely linked to smallpox; House must make a dangerous decision that puts his life in jeopardy; Wilson and Sam comfort a young patient.
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House chooses a third-year medical student (Amber Tamblyn) when Cuddy forces him to hire a female team member; a politician's campaign manager mysteriously falls ill with liver failure and temporary paralysis.
A man becomes a patient after re-enacting the Crucifixion; Taub questions his wife about her relationship with a member of an infidelity support group; Wilson's relationship with Sam takes an unexpected turn at a co-worker's wedding.
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