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When a young housewife falls ill, House suspects that she has contracted a rare sexually transmitted disease, but she and her husband (Dominic Purcell) each deny having an affair.
Dr. House shows special interest in a schizophrenic with deep-vein thrombosis and her teenage son, who is her primary caregiver.
House and his team investigate the mysterious poisoning of a high-school student, and they think they have the answers they need until a second teen develops the same symptoms.
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