A bus accident robs House of several hours, and as his memory slowly returns, he realizes that one of his fellow passengers was exhibiting signs of a deadly illness, so he races to unlock the secrets in his brain.
House takes matters into his own hands when he feels certain that one of the actors on his favorite soap opera (Jason Lewis) is suffering from a serious medical condition, but the actor dismisses House's assessment.
House's murky memories of the bus crash test his friendship with Wilson and threaten to change their lives forever.
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