A man (Zeljko Ivanek) willing to kill or die for a diagnosis takes House, Thirteen and a number of patients hostage in Cuddy's office, where House tries to come up with the correct diagnosis.
An emancipated minor (Emily Rios) working as a factory manager falls ill on the job; Foreman takes on a pediatric case that has him questioning whether he can function without House's oversight.
House and the team treat a high-profile fitness trainer who collapses while shooting an infomercial; Thirteen participates in a clinical trial led by Foreman.
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