After being found in a coma at his apartment, a 600-pound man is admitted to the hospital; House spends the night in jail after being arrested for a number of violations.
House treats a young married couple with similar symptoms, but they are shocked by the cause of the illness; a walk-in patient (David Morse) stands up to House.
Symptoms point to a possible genetic connection when House notices something about the son of a man (John Larroquette) who has been in a coma for a decade; Wilson confronts House about stealing his prescription pad.
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