J.D. and Turk re-evaluate their career choices when they are visited by a successful college buddy (guest star Ryan Reynolds); Dr. Cox learns the truth about his relationship to Jordan's baby.
Carla reconsiders her wedding plans with Turk after her mother dies unexpectedly; J.D. turns to Elliot for advice on romance.
J.D. turns to Carla and Turk for help diagnosing a patient with puzzling symptoms; running into her former flame (Scott Foley) prompts Elliot to undergo a complete makeover.