J.D. turns to Carla and Turk for help diagnosing a patient with puzzling symptoms; running into her former flame (Scott Foley) prompts Elliot to undergo a complete makeover.
J.D. and Turk re-evaluate their career choices when they are visited by a successful college buddy (guest star Ryan Reynolds); Dr. Cox learns the truth about his relationship to Jordan's baby.
When Turk and Carla set a date for their wedding, J.D. worries he may lose Turk's friendship; Elliot vows to win back her ex-boyfriend (Scott Foley).