Meek housewife Thelma joins her friend Louise, an independent waitress, on a short fishing trip. However, their trip becomes a flight from the law when Louise shoots and kills a man who tries to rape Thelma at a bar. Louise decides to flee to Mexico, and Thelma joins her. On the way, Thelma falls for sexy young thief J.D. and the sympathetic Detective Slocumb tries to convince the two women to surrender before their fates are sealed.