Texas at Oklahoma State
No. 22 Texas tries to remain in the Top 25, when the Longhorns open Big 12 play at Oklahoma State. Texas reached as high as No. 11 after beating Notre Dame in Week 1, while the Cowboys have fallen out of the polls after starting the season at No. 21.
Wisconsin at Michigan
No. 4 Michigan faces its first real test of the season when No. 8 Wisconsin comes to town. The Wolverines (4-0) have defeated Hawaii, UCF, Colorado and Penn St. easily, while the Badgers (4-0) have downed LSU, Akron, Georgia State and Michigan State.
Louisville at Clemson
No. 5 Clemson hosts No. 3 Louisville in a huge ACC Atlantic showdown. The Tigers (4-0) have played much better the past two weeks after a sluggish start, while the Cardinals (4-0) continue to dominate offensively.